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May 1, 2002Journal of Biological ChemistryOpen Access

Active Site Mutation in DNA Polymerase γ Associated with Progressive External Ophthalmoplegia Causes Error-prone DNA Synthesis

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Authors

MPMikhail V. PonamarevHospital for Sick ChildrenMLMatthew J. LongleyNational Institutes of HealthDNDinh C. NguyenUniversity of Alabama in Huntsville

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Ponamarev et al. (2002) studied this question.

synapsesocial.com/papers/6a8a9c5451cd0cd12ac15ec0https://doi.org/10.1074/jbc.c200100200
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Also Consider

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  1. 1A mutant of DNA polymerase I (Klenow fragment) with reduced fidelity1991 · 125 citations
  2. 2Characterization of the Native and Recombinant Catalytic Subunit of Human DNA Polymerase γ: Identification of Residues Critical for Exonuclease Activity and Dideoxynucleotide Sensitivity1998 · 177 citations
  3. 3Identification of residues critical for the polymerase activity of the Klenow fragment of DNA polymerase I from Escherichia coli.1990 · 260 citations
  4. 4Mitochondrial DNA polymerase from Drosophila melanogaster embryos: kinetics, processivity, and fidelity of DNA polymerization1988 · 42 citations
  5. 5Mitochondrial disease in mouse results in increased oxidative stress1999 · 641 citations