A Xenopus Nonmuscle Myosin Heavy Chain Isoform Is Phosphorylated by Cyclin-p34cdc2 Kinase during Meiosis

View Full Paper

Ask AI

Bookmark

Population

Cultured Xenopus XTC cells, Xenopus eggs, and Xenopus oocytes

Design

Preclinical

Authors

Discussion

Supports differential MHC isoform functions; leaves open relevance to human cardiac biology and requires mammalian validation.

Population

Cultured Xenopus XTC cells, Xenopus eggs, and Xenopus oocytes

Intervention

In vitro phosphorylation with cdc2 kinase and in vivo observation during cell cycle stages

Outcome

Phosphorylation of MHC-B isoforms at Ser-214surrogate

MHC-B phosphorylation is tightly regulated by cdc2 kinase during meiotic cell cycles, suggesting differential functions for MHC-A and MHC-B isoforms.

Kelley et al. (1995) studied this question.

View Full Paper

Ask AI

Bookmark