Evidence that cyclic GMP may regulate the association of myosin II heavy chain with the cytoskeleton by inhibiting its phosphorylation

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Structured PICO

Population

Dictyostelium discoideum (wild-type strain NC4, parental strain XP55, and streamer mutants NP368 and NP377)

Intervention

Cyclic AMP stimulation

Comparator

Comparison between wild-type/parental strains and streamer mutants (NP368 and NP377)

Outcome

Myosin II heavy chain (MHC) phosphorylation and association with the cytoskeletonsurrogate

Cyclic GMP may regulate myosin II heavy chain association with the cytoskeleton by inhibiting its phosphorylation in Dictyostelium discoideum.

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May indicate cGMP regulation of myosin in Dictyostelium; leaves open relevance to mammalian cardiac myosin dynamics.

Liu et al. (1991) studied this question.

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