June 1, 1993Journal of VirologyOpen Access

RNA-binding properties of a translational activator, the adenovirus L4 100-kilodalton protein

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Population

Adenovirus L4 100-kDa nonstructural protein from uninfected or adenovirus type 5-infected HeLa cells and…

Design

Preclinical

Authors

Discussion

Indicates nonspecific RNA preference by 100K; leaves open mechanism for viral translational control in vivo.

Population

Adenovirus L4 100-kDa nonstructural protein (100K protein) from uninfected or adenovirus type 5-infected HeLa cells and H5ts1 mutant

Intervention

Immunoprecipitation assay and competition assays to analyze RNA-binding properties

Outcome

RNA-binding activity and specificity of the 100K proteinsurrogate

The adenovirus 100K protein acts to increase the translational efficiency of viral late mRNA species by a mechanism that involves binding to RNA.

Riley et al. (1993) studied this question.

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