The human adenovirus 5 E1B 55-kDa protein possesses RNA-binding activity essential for its in vivo function in nucleocytoplasmic transport of late viral mRNAs.
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The human adenovirus 5 E1B 55-kDa protein is required for efficient nucleocytoplasmic transport of late viral mRNAs. This protein is shown to have RNA-binding activity which maps to a region of the protein with homology to a family of RNA-binding proteins and which has been shown previously to be essential for functionality of the protein in vivo.
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RNA-binding by E1B 55-kDa may guide antiviral strategies; leaves open validation beyond animal models.
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Horridge et al. (1998) studied this question.
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