Population
Recombinant WT and mutant Acanthamoeba myosins (heavy meromyosin and myosin subfragment 1)
Comparison
Phosphorylation of Ser639 in loop 2 of the motor… vs Wild-type or unphosphorylated myosins
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether loop 2 modification alters cardiac myosin function in vivo.
This study demonstrates the first example of regulation of actin-activated MgATPase activity of myosin by modification of surface loop 2 via phosphorylation of Ser639.
Liu et al. (2012) studied this question.
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