Contractile activity regulates isoform expression and polysialylation of NCAM in cultured myotubes: involvement of Ca2+ and protein kinase C.

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Population

Developing chick secondary myotubes grown in culture

Comparison

Modulation of contractile activity, Ca2+ channel… vs Unstimulated or unblocked control myotubes

Design

Preclinical

Authors

Discussion

Activity-dependent NCAM regulation in myotubes is hypothesis-generating; leaves open relevance to human cardiac muscle development or repair.

Population

Developing chick secondary myotubes grown in culture

Intervention

Modulation of contractile activity (electrical stimulation or blocking), Ca2+ channel blockers, and protein kinase C inhibitors

Comparator

Unstimulated or unblocked control myotubes

Outcome

Polysialylation of NCAM (PSA expression) and NCAM isoform expressionsurrogate

Contractile activity regulates NCAM polysialylation and isoform expression in developing myotubes via a Ca2+ and protein kinase C-dependent pathway.

Rafuse et al. (1996) studied this question.

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Activity-dependent NCAM regulation in myotubes is hypothesis-generating; leaves open relevance to human cardiac muscle development or repair.