Population
Normal Sprague-Dawley rats (n=11), utilizing in vitro blood-perfused juxtamedullary nephron preparation
Comparison
Rapid step increase in renal arterial pressure… vs Same preparation before interruption of distal…
Design
Preclinical
Authors
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TGF augments myogenic vasoconstriction magnitude in afferent arterioles; leaves open net effects on renal autoregulation in vivo.
The tubuloglomerular feedback mechanism plays a role in both direct mediation of vasoconstriction and modulation of the myogenic response in renal afferent arterioles.
Walker et al. (2000) studied this question.
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