Associations between childhood family stress and systemic inflammation in adulthood: Contributions of pubertal timing and waist circumference in adolescence.

OBJECTIVE: Evidence from retrospective studies suggests that childhood experiences relate to levels of systemic inflammation across the lifespan, particularly for women. This prospective study examined associations between childhood family stress and inflammation in early adulthood among women, considering pubertal timing and adolescent adiposity as potential biobehavioral mediators as well as differences by race. METHOD: = 23.57 years). Household receipt of public assistance between ages 5 and 9 was included as a binary covariate. Age at menarche and waist circumference at age 12 served as mediators in structural equation models. Childhood family stress was also indirectly related to adult IL-6 via pubertal timing (β = .01, confidence interval [0.000, 0.004]) and waist circumference (β = .05, confidence interval [0.002, 0.021]). When modeling both mediators together, only waist circumference contributed independent variance to the association between childhood family stress and adult IL-6, and results varied by race. CONCLUSIONS: Stress within the childhood family environment may relate to long-term systemic inflammation, both directly and indirectly through pubertal timing and adolescent adiposity, independently of household public assistance. The identification of life course cascades underlying cardiometabolic risk could inform early health promotion efforts. (PsycInfo Database Record (c) 2026 APA, all rights reserved).