What does this research mean for the field?

In maintenance hemodialysis patients, low time-weighted parathyroid hormone (PTH) levels are associated with adverse nutritional-inflammatory profiles, greater functional dependence, and higher mortality. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the associations between longitudinal parathyroid hormone (PTH) burden and nutritional-inflammatory profiles, functional dependence, hospitalization, and mortality in adults on maintenance hemodialysis.

August 23, 2026NutrientsOpen Access

Low Time-Weighted Parathyroid Hormone Is Associated with Malnutrition-Inflammation and Functional Dependence in Maintenance Hemodialysis

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Authors

NINomy Levin IainaBen-Gurion University of the Negev APAlexandra PetkutsaBarzilai Medical Center NHNayaf HabashiBar-Ilan University

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Implication

Retrospective cohort study reveals that low parathyroid hormone tracks with malnutrition, frailty, and higher mortality in hemodialysis, indicating risks associated with overly suppressed hormone...

Key Points

To evaluate the associations between longitudinal parathyroid hormone (PTH) burden and nutritional-inflammatory profiles, functional dependence, hospitalization, and mortality in adults on maintenance hemodialysis.
Retrospective cohort study of 188 adults receiving maintenance hemodialysis with serial PTH measurements summarized using time-weighted means.
Nutritional, inflammatory, and functional outcomes were analyzed via regression models, while mortality was evaluated using a joint longitudinal–survival model adjusted for age, sex, dialysis vintage, and dialysis access, alongside a 6-month landmark analysis (N=159).
Lower longitudinal PTH burden was associated with adverse nutritional-inflammatory markers (lower albumin, cholesterol, transferrin; higher C-reactive protein, ferritin) and higher odds of functional dependence in mobility, dressing, bathing, toileting, and continence.
Across 62 total deaths, each twofold increase in estimated current PTH in the joint model was associated with reduced mortality (adjusted HR 0.58, 95% CI 0.46–0.73; p < 0.001), while hospitalization showed no significant association.
In the 6-month landmark sensitivity analysis (44 deaths), PTH < 150 pg/mL was associated with higher mortality compared to PTH 300–600 pg/mL (HR 2.84, 95% CI 1.22–6.63), with each twofold increase in PTH yielding an HR of 0.69 (95% CI 0.51–0.95; p = 0.021).

Cite This Study

Iaina et al. (2026) studied this question.

synapsesocial.com/papers/6a8aada77677a34114445de8 https://doi.org/10.3390/nu18162742

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Implication

Retrospective cohort study reveals that low parathyroid hormone tracks with malnutrition, frailty, and higher mortality in hemodialysis, indicating risks associated with overly suppressed hormone...

Low Time-Weighted Parathyroid Hormone Is Associated with Malnutrition-Inflammation and Functional Dependence in Maintenance Hemodialysis

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Key Points

Cite This Study

Low Time-Weighted Parathyroid Hormone Is Associated with Malnutrition-Inflammation and Functional Dependence in Maintenance Hemodialysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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