What does this research mean for the field?

Specific subgingival microbiota patterns characterize healthy, gingivitis, and periodontitis states in an Indonesian population, with pathogen re-colonization occurring 3 months post-therapy, suggesting the need for periodontal recall within 1 to 3 months. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

To characterize oral microbiome composition across healthy, gingivitis, and periodontitis clinical states and assess subgingival microbial changes following periodontal therapy.

August 23, 2026Dentistry JournalOpen Access

Oral Microbiome Signatures in Indonesian Healthy, Gingivitis, and Periodontitis Subjects: A 16S rRNA Next-Generation Sequencing Analysis-Based Exploratory Study

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Authors

BSBenso SulijayaUniversity of Indonesia MPMelinda Rabekka Putra MPMardikacandra Manggala PutraUniversity of Indonesia

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Implication

Exploratory study reveals distinct subgingival microbiome shifts during periodontal disease and therapy, suggesting pathogen recolonization within three months.

Key Points

To characterize oral microbiome composition across healthy, gingivitis, and periodontitis clinical states and assess subgingival microbial changes following periodontal therapy.
Enrolled 12 subjects categorized into healthy, gingivitis, and periodontitis groups, with the periodontitis cohort monitored longitudinally at baseline, 1 month, and 3 months post-therapy.
Collected subgingival dental plaque samples and performed 16S rRNA next-generation sequencing to evaluate taxonomic composition, alpha diversity (Chao1, Shannon, Simpson), and beta diversity (Bray–Curtis dissimilarity PCoA).
Alpha diversity indices showed no statistically significant differences between groups (p > 0.05), and beta diversity showed clinical status accounted for 21.9% of variation at the genus level (R2 = 0.219, p = 0.197) and 19.8% at the species level (R2 = 0.198, p = 0.281).
Healthy subjects showed higher relative abundance of Veillonella parvula, Campylobacter gracilis, and Capnocytophaga granulosa, whereas Prevotella oris and Selenomonas noxia were enriched in gingivitis and periodontitis.
In periodontitis patients, periodontal therapy reduced Porphyromonas gingivalis at 1 month, but levels rebounded by 3 months post-treatment, with periodontitis samples showing no distinct clustering over time (genus R2 = 0.076, p = 0.097; species R2 = 0.097, p = 0.995).

Cite This Study

Sulijaya et al. (2026) studied this question.

synapsesocial.com/papers/6a8aae007677a341144469a5 https://doi.org/10.3390/dj14080532

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Implication

Exploratory study reveals distinct subgingival microbiome shifts during periodontal disease and therapy, suggesting pathogen recolonization within three months.

Oral Microbiome Signatures in Indonesian Healthy, Gingivitis, and Periodontitis Subjects: A 16S rRNA Next-Generation Sequencing Analysis-Based Exploratory Study

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Key Points

Cite This Study

Oral Microbiome Signatures in Indonesian Healthy, Gingivitis, and Periodontitis Subjects: A 16S rRNA Next-Generation Sequencing Analysis-Based Exploratory Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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