What does this research mean for the field?

Specific nutritional strategies, including caloric restriction, the Mediterranean diet, and intermittent fasting, are associated with reduced biological age, whereas inflammatory diets and obesity accelerate aging, with dietary patterns differentially affecting organ-specific aging trajectories. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To review the effects of nutritional interventions on molecular and omics-based markers of biological age in model organisms and humans.

August 23, 2026Annual Review of NutritionOpen Access

Nutritional Strategies for Targeting Biological Age

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To review the effects of nutritional interventions on molecular and omics-based markers of biological age in model organisms and humans.
Synthesized findings from preclinical studies and clinical trials evaluating dietary patterns, including caloric restriction, intermittent fasting, and Mediterranean diets.
Evaluated omics-based aging biomarkers and proteomic datasets measuring system-level and organ-specific biological aging rates.
Caloric restriction, Mediterranean dietary patterns, intermittent fasting, and micronutrient supplementation associate with measurable reductions in biological age.
Obesity, malnutrition, and pro-inflammatory diets correlate with accelerated biological aging trajectories across varied measurement platforms.
Proteomic evidence demonstrates that distinct organ systems age at heterogeneous rates and respond differentially to targeted nutritional strategies.

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Implication

Review reveals that specific dietary patterns and caloric restriction slow biological aging across organisms, highlighting the potential of precision nutrition to improve healthspan.

Cite This Study

Albright et al. (2026) studied this question.

synapsesocial.com/papers/6a8aae337677a34114446ffb https://doi.org/10.1146/annurev-nutr-062322-025848

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Implication

Review reveals that specific dietary patterns and caloric restriction slow biological aging across organisms, highlighting the potential of precision nutrition to improve healthspan.

Nutritional Strategies for Targeting Biological Age

Key Points

Discussion

Implication

Cite This Study

Nutritional Strategies for Targeting Biological Age

Key Points

Discussion

Implication

Cite This Study

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