Prognostic Accuracy of Clinical Markers of Postpartum Bleeding in Predicting Maternal Mortality or Severe Morbidity: A WHO Individual Participant Data Meta-Analysis

( Lancet 2025;406:1969–1982. doi: 10.1016/S0140-6736(25)01639-3) Postpartum hemorrhage (PPH), defined as excessive bleeding following childbirth, remains one of the leading causes of maternal death and severe morbidity worldwide, particularly in low- and middle-income countries. Despite advances in obstetric care, there is no universally agreed-upon definition of what constitutes clinically dangerous PPH, and commonly used blood loss thresholds may not reliably identify women at greatest risk of life-threatening outcomes. This study aimed to evaluate how accurately commonly used clinical markers of PPH predict maternal mortality or severe morbidity.