What does this research mean for the field?

Chronic Q fever frequently presents as cardiovascular infection, involves substantial diagnostic delays, and often requires surgical intervention in addition to prolonged antimicrobial therapy. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate clinical manifestations, diagnostic timelines, therapeutic regimens, and outcomes among patients diagnosed with chronic Q fever.

August 23, 2026Open Forum Infectious DiseasesOpen Access

Retrospective Analysis of Chronic Q Fever Cases at a Tertiary Care Center from 2007 to 2023

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Authors

MDMitchell DumaisNational Institute of Allergy and Infectious Diseases JHJames F. HowickJacksonville College SGSofia Molina GarciaMayo Clinic

Discussion

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Implication

Retrospective cohort study reveals prolonged diagnostic delays and high surgical rates in chronic Q fever, highlighting the need for early infectious disease consultation.

Key Points

To evaluate clinical manifestations, diagnostic timelines, therapeutic regimens, and outcomes among patients diagnosed with chronic Q fever.
Retrospective cohort study of patients (N=33) diagnosed with chronic Q fever at Mayo Clinic between 2007 and 2023.
Inclusion criteria required clinical evidence plus a phase I IgG titer ≥1:1024, a positive Coxiella burnetii PCR, or both.
Electronic health record data were analyzed for exposures, clinical presentations, diagnostics, medical and surgical treatments, and mortality.
Median overall time to diagnosis was 99 days, whereas the interval from Infectious Diseases evaluation to diagnosis was 11.4 days; 52% (n=17) had animal exposure and 24% (n=8) had no identifiable exposure.
Predominant manifestations were prosthetic valve endocarditis (42%, n=14) and vascular graft infection (27%, n=9).
Most patients received doxycycline and hydroxychloroquine (75%, n=25), 42% (n=14) required surgical intervention, and disease-attributable mortality was 6% (n=2).

Cite This Study

Dumais et al. (2026) studied this question.

synapsesocial.com/papers/6a8aae407677a3411444729d https://doi.org/10.1093/ofid/ofag542

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Implication

Retrospective cohort study reveals prolonged diagnostic delays and high surgical rates in chronic Q fever, highlighting the need for early infectious disease consultation.

Retrospective Analysis of Chronic Q Fever Cases at a Tertiary Care Center from 2007 to 2023

Discussion

Member takes

Implication

Key Points

Cite This Study

Retrospective Analysis of Chronic Q Fever Cases at a Tertiary Care Center from 2007 to 2023

Discussion

Member takes

Implication

Key Points

Cite This Study

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