What question did this study set out to answer?

To review the clinical characteristics and spectrum of disease in patients with serologically confirmed chronic or fatal Q-fever infection.

January 1, 1983QJM

Chronic or Fatal Q-Fever Infection: A Review of 16 Patients Seen in North-East Scotland (1967–80)

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Authors

MEMatthew EllisUniversity of Manchester CSCatherine C. SmithUniversity of California, San Francisco MMMargaret A. J. MoffatUniversity of Dundee

Discussion

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Implication

Retrospective review reveals diverse extra-valvular manifestations in chronic Q-fever infection, indicating that serological screening should extend beyond culture-negative endocarditis.

Key Points

To review the clinical characteristics and spectrum of disease in patients with serologically confirmed chronic or fatal Q-fever infection.
Retrospective review of 16 patients with serologically confirmed Coxiella burnetii infection evaluated between 1967 and 1980.
Evaluation of phase I and phase II antibody titres alongside cardiac pathology and non-cardiac manifestations.
Fifteen patients demonstrated significantly elevated antibody titres to both phase I and phase II antigens, while one infant had elevated phase II titres only.
Only 7 of 16 patients presented with valvular endocarditis, occurring primarily on prosthetic valves, congenitally bicuspid valves, or valves damaged by rheumatic or syphilitic disease.
Eight patients exhibited extra-valvular manifestations, including abdominal aortic dacron graft endocarditis, ventricular colonization, transplacental infection causing perinatal death, and sudden infant death syndrome.

Cite This Study

Ellis et al. (1983) studied this question.

synapsesocial.com/papers/6a9fa20b7b6409934544a539 https://doi.org/10.1093/oxfordjournals.qjmed.a067742

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Implication

Retrospective review reveals diverse extra-valvular manifestations in chronic Q-fever infection, indicating that serological screening should extend beyond culture-negative endocarditis.

Chronic or Fatal Q-Fever Infection: A Review of 16 Patients Seen in North-East Scotland (1967–80)

Discussion

Member takes

Implication

Key Points

Cite This Study

Chronic or Fatal Q-Fever Infection: A Review of 16 Patients Seen in North-East Scotland (1967–80)

Discussion

Member takes

Implication

Key Points

Cite This Study

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