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August 23, 2026MedicineOpen Access

A comparative analysis of the pregnancy outcomes of IVF-ET in postoperative infertile patients with endometriosis treated with platelet-rich plasma and G-CSF

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Authors

CZCuijuan ZhouGuigang City People's HospitalJLJinglan LuGuigang City People's HospitalWHWeimei HuangGuangxi Medical University

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Implication

Comparative study demonstrates intrauterine PRP and G-CSF similarly improve endometrial receptivity and pregnancy rates in endometriosis-related infertility, suggesting equivalent efficacy.

Key Points

  • To compare the effects of intrauterine platelet-rich plasma (PRP) versus granulocyte colony-stimulating factor (G-CSF) on endometrial receptivity and IVF-ET pregnancy outcomes in postoperative endometriosis patients.
  • Assessed infertile patients with endometriosis who underwent elective laparoscopic surgery and subsequent IVF-ET.
  • Assigned patients to PRP + IVF-ET, G-CSF + IVF-ET, or control groups.
  • Measured endometrial thickness, endometrial morphology, uterine artery blood flow metrics, pregnancy outcomes, and adverse reactions.
  • Both PRP and G-CSF groups showed significantly higher endometrial thickness and lower uterine artery resistance index, pulsatility index, and flow velocity post-treatment (P < .05).
  • Endometrial morphology types A and B and blood flow types II and I–II significantly increased in both treatment arms relative to pre-treatment levels (P < .05).
  • No statistically significant differences in uterine vascular indices, endometrial morphology, or adverse reactions were observed between the PRP and G-CSF arms (P > .05).

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/6a8aae507677a34114447403https://doi.org/10.1097/md.0000000000050103
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Granulocyte colony-stimulating factor priming improves embryos and pregnancy rate in patients with poor ovarian reserve: a randomized controlled trial2023 · 12 citations
  2. 2An update on platelet-rich plasma (PRP) therapy in endometrium and ovary related infertilities: clinical and molecular aspects2021 · 80 citations
  3. 3Endometriosis-associated infertility: From pathophysiology to tailored treatment2022 · 331 citations
  4. 4Autologous platelet-rich plasma optimizes endometrial thickness and pregnancy outcomes in women with refractory thin endometrium of varied aetiology during fresh and frozen-thawed embryo transfer cycles2021 · 58 citations
  5. 5Role of suppression of endometriosis with progestins before IVF-ET: a non-inferiority randomized controlled trial2021 · 51 citations