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September 10, 2025Clinical and Experimental Obstetrics & GynecologyOpen Access

Effect of Intrauterine Autologous Platelet-Rich Plasma Instillation in Infertile Women With Thin Endometrium Undergoing Frozen-Thawed Embryo Transfer: A Randomized Controlled Trial

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Authors

SPSootthinan PothisanPLPitak LaokirkkiatSPSomsin Petyim

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Overview

Randomized controlled trial assessed endometrial thickness in infertile women undergoing FET, revealing insights on PRP impact.

Key Points

  • Single intrauterine PRP instillation on day 8 may improve endometrial thickness, yet results lack statistical significance.
  • The PRP-1 group showed an increase in endometrial thickness of 1.52 ± 1.10, compared to lower values in other groups.
  • Repeated PRP administration resulted in a significant cycle cancellation rate of 77.78%, indicating potential limitations.
  • Control group pregnancy rates were notably higher, with 42.85% for clinical pregnancies compared to lower rates in PRP groups.

Cite This Study

Pothisan et al. (2025) studied this question.

synapsesocial.com/papers/68c1bb5b54b1d3bfb60ecc8ahttps://doi.org/10.31083/ceog39260
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Autologous platelet-rich plasma as a potential new approach in the endometrial response during <i>in vitro</i> fertilization cycle: A pilot study2024 · 1 citations
  2. 2P-294 Intrauterine infusion of autologous platelet-rich plasma(PRP) for patients with refractory thin endometrium in euploid frozen embryo transfer cycles improve pregnancy outcomes2024
  3. 3Intrauterine infusion and sub-endometrial injection of autologous platelet-rich plasma for thin endometrium: A systematic review and single-arm meta-analysis2026
  4. 4Angiogenic factor-driven improvement of refractory thin endometrium with autologous platelet-rich plasma intrauterine infusion in frozen embryo transfer cycles2024 · 13 citations
  5. 5Comparison of the efficacy of single vs. double autologous platelet-rich plasma intrauterine infusion on endometrial receptivity in thin endometrium patients: a prospective randomized controlled trial2025 · 5 citations