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September 5, 2025Frontiers in EndocrinologyOpen Access

Comparison of the efficacy of single vs. double autologous platelet-rich plasma intrauterine infusion on endometrial receptivity in thin endometrium patients: a prospective randomized controlled trial

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Authors

KFKeng FengLZLingling ZhuYLYudi Luo

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Overview

Randomized controlled trial compares single and double platelet-rich plasma infusion effects on endometrial receptivity in patients with thin endometrium, highlighting improved pregnancy outcomes.

Key Points

  • Double PRP infusion notably enhanced endometrial thickness by 0.46 mm compared to single infusion, indicating better receptivity.
  • Clinical pregnancy rates were significantly higher at 48.9% for double PRP infusion, against 27.0% for single infusion, suggesting better outcomes.
  • Statistical analysis revealed improved hemodynamic parameters for the double infusion group, emphasizing its potential benefits in treatment.
  • Despite improved rates, early miscarriage rates remained similar between groups, indicating a need for further investigation into underlying factors.

Cite This Study

Feng et al. (2025) studied this question.

synapsesocial.com/papers/68bb3d552b87ece8dc955e8ehttps://doi.org/10.3389/fendo.2025.1609556
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