Why the study?
Does administration of propranolol or practolol differentially block cardiac and bronchiolar responses to sympathetic stimulation in pithed guinea-pigs?
Population
Pithed guinea-pigs
Comparison
Beta-adrenoceptor blocking agents vs Injected catecholamines and unblocked electrical…
Design
Preclinical
Authors
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Suggests practolol cardioselectivity in sympathetic blockade; leaves open translation to human beta-blocker use.
Does administration of propranolol or practolol differentially block cardiac and bronchiolar responses to sympathetic stimulation in pithed guinea-pigs?
Practolol demonstrates cardioselective beta-blockade compared to the non-selective propranolol in a pithed guinea-pig model of sympathetic stimulation.
BURDEN et al. (1972) studied this question.
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