Why the study?
Does intravenous isoprenaline cause cardio-toxicity and mortality in dogs during hypoxia?
Population
Dogs artificially respired with room air or with 12% oxygen-88% nitrogen (hypoxia model)
Comparison
Intravenous injection of isoprenaline vs Normoxemic conditions vs hypoxemic conditions
Design
Preclinical
Authors
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May indicate isoprenaline risk in hypoxia; leaves open translation to human patients.
Does intravenous isoprenaline cause cardio-toxicity and mortality in dogs during hypoxia?
Isoprenaline induces fatal cardiac asystole in hypoxemic dogs at doses that are well-tolerated in normoxemic dogs, an effect that can be prevented by propranolol.
Collins et al. (1969) studied this question.
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