Key result
Adriamycin administration in rats caused dose-dependent increases in partial depurination of dGMP and dAMP and the emergence of new DNA adducts.
Population
36 male Sprague-Dawley rats
Comparison
Doxorubicin hydrochloride 4 mg/kg or 6 mg/kg via… vs 0.9% saline intraperitoneal injection
Design
Preclinical, randomized
Follow-up
48 hours
Authors
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DNA adduct quantification merits exploration as an early anthracycline cardiotoxicity biomarker; leaves open human translation and clinical utility.
RCT (n=36)
randomized
Quantification of specific DNA adducts in myocardial tissue may represent an early biomarker for anthracycline-induced cardiotoxicity.
Hahm et al. (2003) conducted an RCT in Anthracycline cardiomyopathy (n=36). Adriamycin vs. 0.9% saline i.p. was evaluated on DNA adduct formation. Adriamycin administration in rats caused dose-dependent increases in partial depurination of dGMP and dAMP and the emergence of new DNA adducts.
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