Why the study?
Does prenylamine prevent adriamycin-induced cardiotoxicity in patients receiving adriamycin?
Population
26 patients receiving Adriamycin i.v. at standard oncological doses up to 550 mg/m2. Group A mean age 59.7…
Comparison
Prenylamine 200 mg/day orally added to Adriamycin vs Matching placebo orally added to Adriamycin
Design
RCT, randomized in two groups, double-blind
Follow-up
two months after the administration of the last dose of…
Authors
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May mitigate adriamycin cardiotoxicity; leaves open efficacy pending larger confirmatory RCTs.
Does prenylamine prevent adriamycin-induced cardiotoxicity in patients receiving adriamycin?
Simultaneous administration of prenylamine may mitigate adriamycin-induced cardiotoxicity, though larger trials are needed to confirm these pilot findings.
Milei et al. (1987) studied this question.
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