Key result
Activation of AMP-activated protein kinase (AMPK) may inhibit protein synthesis and serve as a potential strategy to prevent the development of cardiac hypertrophy.
AMPK activation is discussed as a potential strategy to prevent cardiac hypertrophy through the inhibition of protein synthesis.
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Hypothesis-generating for AMPK activation to prevent hypertrophy; prospective trials needed before clinical consideration.
Chan et al. (2005) conducted a review in Cardiac hypertrophy. Activation of AMP-activated protein kinase (AMPK) was evaluated. Activation of AMP-activated protein kinase (AMPK) may inhibit protein synthesis and serve as a potential strategy to prevent the development of cardiac hypertrophy.
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