Key result
The presence of extra-articular manifestations in rheumatoid arthritis was associated with significantly higher disease activity scores at 6 months compared to patients without such manifestations (DAS28 5.52 vs 4.29, p<0.001).
Cross-Sectional (n=50)
No
Absolute Event Rate: 5.52% vs 4.29%
p-value: p=<0.001
Extra-articular manifestations are highly prevalent in rheumatoid arthritis patients and are associated with worse disease activity.
Suggests extra-articular manifestations may serve as clinical markers for refractory rheumatoid arthritis;.
Objective: This study was done to determine frequency of extra-articular manifestations (ExRA) in patients with rheumatoid arthritis (RA) and its relation with treatment outcome in a tertiary care hospital, Dhaka.Methods: A cross sectional study was conducted upon 50 patients of rheumatoid arthritis of both gender aged ranging 30 to 60 years attending different medicine units of Shaheed Suhrawardy Medical College & Hospital during the period of May to October, 2011 who fulfilled the 1987 American College of Rheumatology criteria for RA. Demographic characteristics, extra-articular manifestations were recorded and some information was gathered by document review according to DAS28 (disease activity score 28.)Results: Among 50 patients female to male ratio was 9:1. The average age was 43.72±10.95 (SD) in years with maximum age 60 years and minimum age 30 years. Extra-articular manifestations were reported in 86.0% of patients. Hematological involvement (82%) was the most common extra-articular manifestation. Average DAS 28 was more in patients who had extra-articular manifestations than patients who had no extra -articular manifestation.Conclusion: Significant proportion of patients with female predominance visited at a tertiary care hospital due to RA. ExRA were present in a substantial proportion of a hospital based sample and is generally associated with a worse disease outcome. Hematological system involvement was the commonest. Early recognition and treatment are important to decrease disease activity.KYAMC Journal Vol. 6, No.-1, Jul 2015, Page 570-573
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Akter et al. (2017) conducted a cross-sectional in Rheumatoid arthritis (n=50). Extra-articular manifestations vs. No extra-articular manifestations was evaluated on Disease Activity Score 28 (DAS28) at 3rd follow-up (p=<0.001). The presence of extra-articular manifestations in rheumatoid arthritis was associated with significantly higher disease activity scores at 6 months compared to patients without such manifestations (DAS28 5.52 vs 4.29, p<0.001).
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