Key result
Cardiac transplantation restores function in end-stage disease despite ~59% mortality from rejection and sepsis.
Why the study?
Human cardiac transplantation was evaluated as potential palliation for patients with end-stage cardiac disease who had no other available treatments.
Does cardiac transplantation provide palliation and effective cardiac function in patients with end-stage cardiac disease?
Population
17 patients undergoing 18 heart transplants
Design
Case series
Authors
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Early transplant experience shows functional recovery despite high rejection mortality; leaves open optimization of immunosuppression before wider adoption.
Case Report (n=17)
Does cardiac transplantation provide palliation and effective cardiac function in patients with end-stage cardiac disease?
Early experience with human cardiac transplantation demonstrates it can provide effective cardiac function for end-stage heart disease, though it is limited by high mortality from rejection and infection.
Cooley et al. (1969) conducted a case report in End-stage cardiac disease (n=17). Cardiac transplantation was evaluated. Cardiac transplantation in 17 patients with end-stage cardiac disease provided effective cardiac function for survivors, though 10 deaths occurred from rejection, sepsis, and other causes.
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