Key result
Top-down mass spectrometry identified 23 protein isoforms with 46 proteoforms of sarcomeric proteins, including a novel PDLIM7 isoform, in rhesus macaque skeletal muscle.
Why the study?
Non-human primates are valuable models for sarcopenia, but sarcomeric proteins in their skeletal muscle have not been well characterized.
Population
Rhesus macaque skeletal muscle
Design
Top-down mass spectrometry analysis
Authors
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Offers a nonhuman primate reference for sarcomeric proteoforms; leaves open translation to human cardiac muscle in health and disease.
Top-down mass spectrometry successfully characterized multiple isoforms and post-translational modifications of sarcomeric proteins in non-human primate skeletal muscle, providing a baseline for studying muscle diseases like sarcopenia.
Jin et al. (2019) studied this question. Top-down mass spectrometry was evaluated on Identification of isoforms and post-translational modifications of sarcomeric proteins. Top-down mass spectrometry identified 23 protein isoforms with 46 proteoforms of sarcomeric proteins, including a novel PDLIM7 isoform, in rhesus macaque skeletal muscle.
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