Key result
Human parechoviruses exhibit a high substitution rate of 2.79 × 10^-3 substitutions per site per year for the VP1 region, with the most recent common ancestor estimated to have emerged around the year 1600.
Population
29 nucleotide sequences from the P1 structural region and 199 nucleotide sequences of the VP1 capsid region…
Design
Other
Authors
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High substitution rates in parechoviruses support ongoing diversification; leaves open needs for enhanced surveillance and vaccine updates.
Effect estimate: 2.79 × 10^-3 (95% CI 2.05 × 10^-3 - 3.66 × 10^-3)
Human parechoviruses exhibit high evolutionary substitution rates, with the genetic diversity of currently circulating types having arisen approximately 400 years ago.
Faria et al. (2009) studied Human parechovirus (HPeV) (n=228). Evolutionary time was evaluated on Substitution rate of the VP1 capsid region (substitutions per site per year) (2.79 × 10^-3, 95% CI 2.05 × 10^-3 - 3.66 × 10^-3). Human parechoviruses exhibit a high substitution rate of 2.79 × 10^-3 substitutions per site per year for the VP1 region, with the most recent common ancestor estimated to have emerged around the year 1600.
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