What question did this study set out to answer?

To determine whether adrenal glands and glucocorticoid release are required for the acute inhibition of gonadotropin secretion induced by corticotropin-releasing hormone in primates.

April 1, 1989Endocrinology

Acute Inhibition of Gonadotropin Secretion by Corticotropin-Releasing Hormone in the Primate: Are the Adrenal Glands Involved?*

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Authors

EXEnnian XiaoColumbia University JLJohannes LuckhausUniversity of Bonn WNWendell H. NiemannIcahn School of Medicine at Mount Sinai

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Implication

Experimental study shows corticotropin-releasing hormone inhibits gonadotropins without adrenal glands in rhesus monkeys, indicating stress acts centrally rather than through cortisol.

Key Points

To determine whether adrenal glands and glucocorticoid release are required for the acute inhibition of gonadotropin secretion induced by corticotropin-releasing hormone in primates.
Administered 5-hour intravenous infusions of corticotropin-releasing hormone (100–150 μg/h) or saline to four ovariectomized rhesus monkeys (N=4) before and after bilateral adrenalectomy.
Tested adrenalectomized monkeys under three glucocorticoid replacement regimens producing mean cortisol levels of 21.9 ± 1.4 μg/dL (group 1), 14.3 ± 1.1 μg/dL (group 2), and <1.0 μg/dL (group 3), with intravenous morphine (9 mg) as a control.
Corticotropin-releasing hormone significantly suppressed gonadotropins in adrenalectomized groups 2 and 3, reducing hour 5 luteinizing hormone area under the curve to 44.6 ± 3.7% and 53.5 ± 6.1%, and hour 4 follicle-stimulating hormone to 76.2 ± 4.7% and 74.7 ± 4.0% of preinfusion baseline.
Group 1 monkeys with high cortisol replacement resisted hormone suppression (hour 5 luteinizing hormone AUC: 96.8 ± 6.2%; hour 4 follicle-stimulating hormone: 95.7 ± 3.5%), despite responding normally to morphine suppression (hour 3 luteinizing hormone: 51.5 ± 11.4%; follicle-stimulating hormone: 61.0 ± 3.2%).
Acute suppression of gonadotropins by corticotropin-releasing hormone does not require adrenal glands or elevated cortisol, indicating that reproductive inhibition during stress is driven by central neural pathways.

Cite This Study

Xiao et al. (1989) studied this question.

synapsesocial.com/papers/6a8ac3e795f0361a9ebe8f2f https://doi.org/10.1210/endo-124-4-1632

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Implication

Experimental study shows corticotropin-releasing hormone inhibits gonadotropins without adrenal glands in rhesus monkeys, indicating stress acts centrally rather than through cortisol.

Acute Inhibition of Gonadotropin Secretion by Corticotropin-Releasing Hormone in the Primate: Are the Adrenal Glands Involved?*

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Implication

Key Points

Cite This Study

Acute Inhibition of Gonadotropin Secretion by Corticotropin-Releasing Hormone in the Primate: Are the Adrenal Glands Involved?*

Discussion

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Implication

Key Points

Cite This Study

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