What question did this study set out to answer?

To assess the immunogenicity, clinical efficacy, and tolerability of pre-seasonal local intranasal hyposensitization using a chemically modified grass pollen allergoid.

August 1, 1977Allergy

Hyposensitization of Patients With Allergic Rhinitis by Intranasal Administration of Chemically Modified Grass Pollen Allergen

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To assess the immunogenicity, clinical efficacy, and tolerability of pre-seasonal local intranasal hyposensitization using a chemically modified grass pollen allergoid.
Administered pre-seasonal intranasal hyposensitization with a chemically modified grass pollen extract (allergoid) to 5 adult patients with grass pollen allergic rhinitis.
Evaluated immune and clinical responses using serum timothy-specific IgE antibody measurements and pre- and post-seasonal nasal provocation tests.
Serum timothy-specific IgE antibody levels increased in all 5 patients following pre-seasonal treatment, confirming allergoid immunogenicity.
Clinical symptom relief during the grass pollen season was rated satisfactory and nasal sensitivity was reduced on provocation tests in 4 of 5 patients.
Intranasal therapy was well tolerated across all 5 patients with no marked side effects reported.

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Implication

Pilot study shows reduced nasal sensitivity and seasonal symptom relief in grass-allergic adults receiving intranasal allergoid therapy, indicating potential for local hyposensitization.

Cite This Study

Deuschl et al. (1977) studied this question.

synapsesocial.com/papers/6a8ac6a4f71b672e3df4459a https://doi.org/10.1111/j.1398-9995.1977.tb01357.x

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Implication

Pilot study shows reduced nasal sensitivity and seasonal symptom relief in grass-allergic adults receiving intranasal allergoid therapy, indicating potential for local hyposensitization.

Hyposensitization of Patients With Allergic Rhinitis by Intranasal Administration of Chemically Modified Grass Pollen Allergen

Key Points

Discussion

Implication

Cite This Study

Hyposensitization of Patients With Allergic Rhinitis by Intranasal Administration of Chemically Modified Grass Pollen Allergen

Key Points

Discussion

Implication

Cite This Study

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