What question did this study set out to answer?

To determine how patient age influences warfarin dose requirements during long-term maintenance and immediate anticoagulant response after initial therapy.

January 1, 1991Age and Ageing

The Association of Age with Dosage Requirement for Warfarin

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Why the study?

Does age affect the dosage requirement and initial response to warfarin therapy?

Population

494 patients in two groups: Group 1 on stable medium- or long-term warfarin therapy, and Group 2 receiving…

Comparison

Warfarin therapy vs Younger patients (comparison across age groups)

Design

Cohort

Follow-up

16 hours for initial dose group; medium- or long-term for…

Authors

MRM. REDWOODAlameda Health System CTClare P. F. TaylorUniversity College Hospital BBBarbara J. BainSt Mary's Hospital

Discussion

Member takes

Implication

Supports standard initial warfarin dosing in elderly; leaves open optimal maintenance adjustments pending prospective trials.

Key Points

To determine how patient age influences warfarin dose requirements during long-term maintenance and immediate anticoagulant response after initial therapy.
Evaluated 364 patients aged 23–89 years receiving stable medium- or long-term warfarin therapy to determine maintenance dose requirements.
Assessed early anticoagulant response at 16 hours following a standard initial 10 mg oral dose in 130 patients aged 15–83 years.
Elderly individuals on stable therapy required a lower average warfarin dose to achieve and maintain target anticoagulation compared with younger individuals.
No significant difference in anticoagulant effect occurred across age groups 16 hours after receiving an initial 10 mg warfarin dose.

Structured PICO

Does age affect the dosage requirement and initial response to warfarin therapy?

Population

494 patients in two groups: Group 1 (n=364, aged 23-89 years) on stable medium- or long-term warfarin therapy, and Group 2 (n=130, aged 15-83 years) receiving an initial standard oral dose of 10 mg of warfarin.

Intervention

Warfarin therapy (maintenance dosing and initial 10 mg oral dose)

Comparator

Younger patients (comparison across age groups)

Outcome

Warfarin dosage requirement for stable anticoagulation and degree of anticoagulation achieved at 16 hourssurrogate

While elderly patients require lower maintenance doses of warfarin, the same initial dosing protocols can be used as in younger patients.

Cite This Study

REDWOOD et al. (1991) studied this question.

synapsesocial.com/papers/6a8ac82ade5ec4e001e3a1cf https://doi.org/10.1093/ageing/20.3.217

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The Association of Age with Dosage Requirement for Warfarin

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The Association of Age with Dosage Requirement for Warfarin

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider