Why the study?
Does patient age affect steady-state plasma levels, clearance, and prothrombin ratio in patients on warfarin?
Population
39 ambulatory patients attending a haematology clinic, plus 1 elderly hospitalized patient
Comparison
Warfarin therapy vs Patients below 65 years of age compared with…
Design
Cross-sectional
Authors
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Supports equivalent warfarin exposure across age groups in ambulatory patients; hypothesis-generating for dose-plasma correlations.
Does patient age affect steady-state plasma levels, clearance, and prothrombin ratio in patients on warfarin?
Patient age (above or below 65 years) does not significantly alter steady-state plasma concentrations, clearance, or prothrombin ratio of warfarin in ambulatory patients.
Hotraphinyo et al. (1978) studied this question.
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