Why the study?
Do age and weight determine the maintenance dose requirements of warfarin in patients attending anticoagulant clinics?
Do age and weight determine the maintenance dose requirements of warfarin in patients attending anticoagulant clinics?
Age and weight are significantly correlated with warfarin maintenance dose requirements and may be valuable considerations when prescribing initial loading or starting doses.
Answers are grounded in this paper and cite their sources.
Findings should not yet guide warfarin dosing; leaves open prospective validation of age-weight effects on maintenance requirements.
A survey of patients attending anticoagulant clinics at a District General Hospital showed the maintenance dose of warfarin to increase with weight and decrease with age. A significant correlation was observed between age and weight considered together and the maintenance dose. It is proposed that consideration of age and weight may be of value when prescribing loading or starting doses of warfarin at initiation of therapy.
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Dobrzański et al. (1983) studied this question.
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