What question did this study set out to answer?

To measure and characterize temporal fluctuations and individual variations of plasma testosterone concentrations in conscious adult male laboratory rodents.

April 1, 1973Endocrinology

Fluctuations in Plasma Testosterone Levels in Adult Male Rats and Mice

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Authors

ABAndrzej BartkeSouthern Illinois University School of Medicine RSRonald E. SteeleNovartis (Switzerland)NMNeal A. MustoWestern University

Discussion

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Implication

Animal physiological study demonstrates marked fluctuations in plasma testosterone levels in adult male rodents, suggesting an irregular, pulsatile pattern of hormone secretion.

Key Points

To measure and characterize temporal fluctuations and individual variations of plasma testosterone concentrations in conscious adult male laboratory rodents.
Measured plasma testosterone concentrations in adult male rats and mice using radioimmunoassay under standardized housing conditions.
Sampled blood from conscious adult male rats via chronic indwelling jugular catheters every 24 hours for 4 to 8 days, and every 30 minutes for 2.5 to 8 hours.
Demonstrated marked individual variability in mice of the same age and strain, with plasma testosterone levels ranging from less than 1 ng/ml to over 30 ng/ml.
Detected 2- to 5-fold fluctuations in plasma testosterone concentrations between serial samples collected at different times within individual rats.

Cite This Study

Bartke et al. (1973) studied this question.

synapsesocial.com/papers/6a8ac83752e1a91077e946cb https://doi.org/10.1210/endo-92-4-1223

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April 1, 1973Endocrinology

Fluctuations in Plasma Testosterone Levels in Adult Male Rats and Mice

View Full Paper

Ask AI

Bookmark

Authors

ABAndrzej BartkeSouthern Illinois University School of Medicine RSRonald E. SteeleNovartis (Switzerland)NMNeal A. MustoWestern University

Discussion

Member takes

Implication

Animal physiological study demonstrates marked fluctuations in plasma testosterone levels in adult male rodents, suggesting an irregular, pulsatile pattern of hormone secretion.

Key Points

To measure and characterize temporal fluctuations and individual variations of plasma testosterone concentrations in conscious adult male laboratory rodents.
Measured plasma testosterone concentrations in adult male rats and mice using radioimmunoassay under standardized housing conditions.
Sampled blood from conscious adult male rats via chronic indwelling jugular catheters every 24 hours for 4 to 8 days, and every 30 minutes for 2.5 to 8 hours.
Demonstrated marked individual variability in mice of the same age and strain, with plasma testosterone levels ranging from less than 1 ng/ml to over 30 ng/ml.
Detected 2- to 5-fold fluctuations in plasma testosterone concentrations between serial samples collected at different times within individual rats.

Cite This Study

Bartke et al. (1973) studied this question.

synapsesocial.com/papers/6a8ac83752e1a91077e946cb https://doi.org/10.1210/endo-92-4-1223

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