Key result
In adult rats, plasma endothelin-1 levels were 3.7-fold higher in females compared to males, with gonadal ET-1 showing distinct ontogeny between sexes.
Effect estimate: 3.7-fold higher
Absolute Event Rate: 2.69% vs 2.41%
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Highlights sex-dimorphic ET-1 regulation in rats; hypothesis-generating for human cardiovascular studies and leaves translation open.
Otani et al. (1998) studied Normal development. Female sex and aging vs. Male sex was evaluated on Plasma and gonadal endothelin-1 (ET-1) levels (3.7-fold higher). In adult rats, plasma endothelin-1 levels were 3.7-fold higher in females compared to males, with gonadal ET-1 showing distinct ontogeny between sexes.
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