Key result
The MHC2TA rs4774C allele was strongly associated with HHV-6A active replication (P=0.0001), and MS patients with both factors showed worse clinical progression at 2 years (P=0.01).
Why the study?
Does the MHC2TA rs4774C allele and HHV-6A active infection affect clinical progression and treatment response in MS patients?
Population
149 multiple sclerosis (MS) patients and 562 healthy Spanish control individuals
Comparison
Presence of MHC2TA rs4774C minor allele and… vs Absence of minor allele C / absence of HHV-6A…
Design
Case-control
Follow-up
2 years
Authors
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Does not support routine MHC2TA testing in MS; leaves open whether HHV-6A interaction modifies progression or treatment response.
Case-Control (n=711)
Does the MHC2TA rs4774C allele and HHV-6A active infection affect clinical progression and treatment response in MS patients?
p-value: p=0.0001
The MHC2TA rs4774C allele is strongly associated with HHV-6A active replication in MS patients, which correlates with worse clinical progression and poorer response to interferon beta.
Álvarez‐Lafuente et al. (2009) conducted a case-control in Multiple sclerosis (n=711). MHC2TA rs4774C allele and HHV-6A active replication vs. Absence of minor allele C or HHV-6A active infection was evaluated on Association of the rs4774C allele with HHV-6A active replication (p=0.0001). The MHC2TA rs4774C allele was strongly associated with HHV-6A active replication (P=0.0001), and MS patients with both factors showed worse clinical progression at 2 years (P=0.01).
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