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January 1, 2006The Showa University Journal of Medical SciencesOpen Access

Soft coronary plaques characterized by MSCT were significantly associated with slow flow or side branch compromise following PCI, whereas hard plaques were associated with dissection or perforation (P = 0.004).

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Why the study?

Does MSCT-based coronary plaque characterization predict procedural complications following PCI in patients with stable angina?

Population

26 patients with chronic stable angina pectoris scheduled for percutaneous coronary intervention with at…

Design

Cohort

Follow-up

Immediate post-PCI

Key result

Soft coronary plaques characterized by MSCT were significantly associated with slow flow or side branch compromise following PCI, whereas hard plaques were associated with dissection or perforation (P = 0.004).

Authors

YKYukihiko KinohiraYAYasushi AkutsuHLHuiling Li

Discussion

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Member takes

Overview

May inform pre-PCI risk stratification; leaves open whether MSCT characterization improves outcomes.

Study Design

Type

Observational (n=26)

Multicenter

No

Structured PICO

Does MSCT-based coronary plaque characterization predict procedural complications following PCI in patients with stable angina?

P
Population
26 patients (mean age 70 years, 31% female) with stable angina pectoris scheduled for percutaneous coronary intervention, evaluated prospectively for 35 stenotic coronary plaques.
E
Exposure
Multislice computed tomography (MSCT) characterization of coronary arterial plaque density (soft, intermediate, hard) prior to PCI
O
Outcome
Complications following PCI (including slow flow, side branch compromise, dissection, and perforation)safety

Main Result

p-value: p=0.004

Pre-procedural MSCT characterization of coronary plaque density can predict specific mechanical and flow complications during PCI.

Limitations

  • Current temporal resolution of 250 ms requires low heart rates and beta-blockers for artifact-free visualization
  • Decreased spatial resolution may sacrifice the accuracy of morphological assessment
  • Small sample size of 26 patients
  • Visualization only available at low heart rates requiring beta-blockers
  • Decreased spatial resolution may sacrifice accuracy of morphological assessment
  • Small sample size

Cite This Study

Kinohira et al. (2006) conducted an observational in Stable angina pectoris (n=26). Coronary arterial plaque configuration characterized by MSCT vs. Different plaque densities (soft, intermediate, hard) was evaluated on Complications following percutaneous coronary intervention (slow flow, side branch compromise, dissection, perforation) (p=0.004). Soft coronary plaques characterized by MSCT were significantly associated with slow flow or side branch compromise following PCI, whereas hard plaques were associated with dissection or perforation (P = 0.004).

synapsesocial.com/papers/6a8acaf3bc51310b2bdebddahttps://doi.org/10.15369/sujms1989.18.143
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