What question did this study set out to answer?

To compare the clinical efficacy and safety of cefotaxime monotherapy against combination therapy with gentamicin plus clindamycin for peritonitis and soft-tissue infections.

September 1, 1982Clinical Infectious Diseases

Clinical Comparison of Cefotaxime with Gentamicin plus Clindamycin in the Treatment of Peritonitis and Other Soft-Tissue Infections

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Authors

HSH. Harlan StoneUniversity of Maryland, Baltimore EMEvelyn S. MorrisEmory University CGCAROL E. GEHEBEREmory University

Discussion

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Implication

Clinical trial demonstrates equal cure rates but lower nephrotoxicity with cefotaxime versus gentamicin and clindamycin in peritonitis, indicating a safer monotherapy alternative.

Key Points

To compare the clinical efficacy and safety of cefotaxime monotherapy against combination therapy with gentamicin plus clindamycin for peritonitis and soft-tissue infections.
Evaluated 112 patients with peritonitis and soft-tissue infections treated for 5 to 10 days.
Administered either intravenous cefotaxime at 20 mg/kg every 6 hours or intravenous gentamicin at 1 mg/kg every 8 hours plus intravenous clindamycin at 5 mg/kg every 6 hours.
The overall clinical cure rate was 82%, with no statistically significant difference in cure rates between the two treatment groups.
Impaired renal function, marked by a 30% increase in serum creatinine, occurred in 6 of the patients (11%) receiving gentamicin plus clindamycin, compared to 0 patients receiving cefotaxime.
Both regimens showed efficacy against aerobic and anaerobic pathogens, although resistance to cefotaxime occurred in Pseudomonas aeruginosa, select Enterobacter isolates, and some anaerobes.

Cite This Study

Stone et al. (1982) studied this question.

synapsesocial.com/papers/6a8acbb6510c7253b5debf32 https://doi.org/10.1093/clinids/4.supplement_2.s439

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Implication

Clinical trial demonstrates equal cure rates but lower nephrotoxicity with cefotaxime versus gentamicin and clindamycin in peritonitis, indicating a safer monotherapy alternative.

Clinical Comparison of Cefotaxime with Gentamicin plus Clindamycin in the Treatment of Peritonitis and Other Soft-Tissue Infections

Discussion

Member takes

Implication

Key Points

Cite This Study

Clinical Comparison of Cefotaxime with Gentamicin plus Clindamycin in the Treatment of Peritonitis and Other Soft-Tissue Infections

Discussion

Member takes

Implication

Key Points

Cite This Study

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