Key result
Changes in MR-proANP concentrations were significantly associated with mortality, with the highest tertile of change increasing risk compared to the lowest (HR 1.58; 95% CI 1.13-2.21; P=0.0078).
RCT (n=1,237)
Yes
Hazard Ratio: 1.58 (95% CI 1.13–2.21)
p-value: p=0.0078
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MR-proANP changes may refine mortality risk stratification in HF; extends prognostic biomarker data from RCTs.
Masson et al. (2010) conducted an RCT in chronic and stable heart failure (n=1,237). MR-proANP concentrations (highest tertile of change) vs. Lowest tertile of change was evaluated on mortality (HR 1.58, 95% CI 1.13-2.21, p=0.0078). Changes in MR-proANP concentrations were significantly associated with mortality, with the highest tertile of change increasing risk compared to the lowest (HR 1.58; 95% CI 1.13-2.21; P=0.0078).
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