Key result
Elevation of ureteral pressure in anesthetized dogs resulted in a reversible increase in renal blood flow to almost twice control values and diminished autoregulatory capacity.
Why the study?
Does gradated ureteral obstruction alter renal autoregulatory capacity and glomerular filtration rate in anesthetized dogs?
Does gradated ureteral obstruction alter renal autoregulatory capacity and glomerular filtration rate in anesthetized dogs?
Elevation of ureteral pressure causes a reversible decrease in preglomerular vascular resistance, diminishing renal autoregulatory capacity.
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Alerts to potential autoregulatory impairment in obstruction; leaves open translation from canine models to human disease.
Navar et al. (2008) studied Ureteral Obstruction. Gradated ureteral obstruction vs. Control values (zero ureteral pressure) was evaluated on Renal blood flow, glomerular filtration rate, and autoregulatory capacity. Elevation of ureteral pressure in anesthetized dogs resulted in a reversible increase in renal blood flow to almost twice control values and diminished autoregulatory capacity.
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