Key result
Catecholamines, vasopressors, high-dose insulin euglycaemic therapy, and veno-arterial ECMO were associated with reduced mortality and improved hemodynamics in beta-blocker poisoning.
Why the study?
Beta-adrenoreceptor antagonist poisoning is a common overdose that can lead to significant morbidity and mortality.
Do specific treatments reduce mortality and improve haemodynamics in patients with beta-blocker poisoning?
Systematic Review (n=141)
Do specific treatments reduce mortality and improve haemodynamics in patients with beta-blocker poisoning?
For beta-blocker poisoning, a graduated response starting with IV fluids and catecholamines/vasopressors, followed by high-dose insulin euglycaemic therapy, and considering VA-ECMO in refractory cases is reasonable despite low-quality evidence.
No takes yet. Share an insight, caveat, or question.
These therapies may improve survival in beta-blocker poisoning; supports current use while leaving open need for RCTs.
Rotella et al. (2020) conducted a systematic review in Beta-adrenoreceptor antagonist (beta-blocker) poisoning (n=141). Treatments for beta-blocker poisoning (catecholamines, vasopressors, high-dose insulin, ECMO) was evaluated on Mortality and improvement in haemodynamic parameters. Catecholamines, vasopressors, high-dose insulin euglycaemic therapy, and veno-arterial ECMO were associated with reduced mortality and improved hemodynamics in beta-blocker poisoning.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: