Key result
The rs6982502 and rs2954029 variants significantly increased the risk of coronary artery disease (OR 2.470, 95% CI 1.219-4.751, p=0.011; and OR 2.174, 95% CI 1.066-4.433, p=0.033, respectively).
Why the study?
The study aimed to replicate the association between CAD and the GWAS-identified SNPs rs2954029 and rs6982502 in an Iranian population.
Are the rs2954029 and rs6982502 variants associated with an increased risk of coronary artery disease in an Iranian population?
Case-Control (n=285)
Are the rs2954029 and rs6982502 variants associated with an increased risk of coronary artery disease in an Iranian population?
Odds Ratio: 2.47 (95% CI 1.219–4.751)
p-value: p=0.011
The TT genotypes of rs2954029 and rs6982502 are significantly associated with an increased risk of coronary artery disease in an Iranian population, replicating previous GWAS findings.
These variants may increase CAD risk; hypothesis-generating and requires validation before informing risk stratification.
Background: Genome-wide association studies (GWAS) have been the primary tool for an unbiased study of the genetic background of coronary artery disease (CAD). They have identified a list of single-nucleotide polymorphisms (SNPs) associated with coronary artery disease (CAD). In this study, we aimed to replicate the association of rs2954029 and rs6982502, a GWAS identified SNP, to CAD in an Iranian population. Methods: A sample of 285 subjects undergoing coronary angiography, including 134 CAD patients and 151 healthy. The genotype determination of rs2954029 and rs6982502 SNPs performed using the high-resolution melting analysis (HRM) technique. Results: Our results revealed that the TT genotype of rs2954029 (p= 0.009) and rs6982502 (p< 0.001) were significantly higher in CAD patients compared with controls. Binary logistic regression showed that rs6982502 and rs2954029 increase the risk of CAD incidence (2.470 times, p= 0.011, 95% CI= [1.219-4.751], and 2.174 times, p= 0.033, 95% CI= [1.066-4.433] respectively). After adjusting for confounders, we found that rs6982502 and rs2954029 are significantly associated with CAD risk. Conclusion: These data showed that the TT genotype of rs2954029 and rs6982502 is associated with the risk of CAD in a hospital-based sample of the Iranian population, which has replicated the result of recent GWAS studies.
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Karimi et al. (2022) conducted a case-control in Coronary Artery Disease (n=285). rs6982502 and rs2954029 variants vs. Healthy controls was evaluated on Coronary artery disease incidence (OR 2.470, 95% CI 1.219-4.751, p=0.011). The rs6982502 and rs2954029 variants significantly increased the risk of coronary artery disease (OR 2.470, 95% CI 1.219-4.751, p=0.011; and OR 2.174, 95% CI 1.066-4.433, p=0.033, respectively).
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