Key result
Human phospholipid transfer protein (PLTP) catalyzes the transfer of phospholipids and vitamin E between lipoprotein particles and plays a key role in HDL formation and homeostasis.
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PLTP is a key protein in HDL homeostasis and atherogenesis, with its activity modulated by apolipoproteins E and A-IV.
Human phospholipid transfer protein (PLTP) is a 476 amino acid secreted protein that catalyzes the transfer of phospholipids and vitamin E between lipoprotein particles. PLTP plays a key role in the formation and homeostasis of high-density lipoprotein (HDL) particles; it transfers phospholipids from very-low-density lipoprotein (VLDL) surface remnants to HDL particles, it facilitates the interconversion of HDL subclasses, and generates lipid-poor pre?-HDL particles. PLTP is synthesized by various cell types but its primary function is in the plasma where it is transported in association with apolipoproteins. Plasma PLTP exists in two forms: a high activity form that co-purifies with apolipoprotein (apo) E and a low activity form associated with apoA-I. It was reported recently that both apoE and apoA-IV can activate PLTP.
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Akopian et al. (2006) conducted a review in Atherogenesis. Phospholipid transfer protein (PLTP) was evaluated. Human phospholipid transfer protein (PLTP) catalyzes the transfer of phospholipids and vitamin E between lipoprotein particles and plays a key role in HDL formation and homeostasis.
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