December 1, 1998The Journal of PhysiologyOpen Access

Ca2+ sparks activate K+ and Cl− channels, resulting in spontaneous transient currents in guinea‐pig tracheal myocytes

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Population

Freshly dissociated guinea-pig tracheal myocytes

Design

Preclinical

Authors

RZRonghua ZhuGeUMass Memorial Health Care SSStephen M. SimsWestern University RTRichard A. TuftWorcester Polytechnic Institute

Discussion

Member takes

Implication

Ca2+ sparks may couple to dual channels in airway myocytes; hypothesis-generating for membrane control and requires human validation.

Structured PICO

Population

Freshly dissociated guinea-pig tracheal myocytes

Intervention

Imaging of local changes in cytosolic [Ca2+] and simultaneous recording of membrane currents using whole-cell, perforated patch recording

Outcome

Relationship between Ca2+ sparks and spontaneous transient currents (STICs, STOCs, STOICs)surrogate

Ca2+ sparks in guinea-pig tracheal myocytes activate both large-conductance Ca2+-activated K+ channels and Ca2+-activated Cl- channels, suggesting a complex spatial organization and potential roles in stabilizing membrane potential or activating voltage-gated Ca2+ channels.

Cite This Study

ZhuGe et al. (1998) studied this question.

synapsesocial.com/papers/6a8ad7cfeada60f85de3a675 https://doi.org/10.1111/j.1469-7793.1998.711ba.x

View Full Paper

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Ca2+ sparks activate K+ and Cl− channels, resulting in spontaneous transient currents in guinea‐pig tracheal myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ca2+ sparks activate K+ and Cl− channels, resulting in spontaneous transient currents in guinea‐pig tracheal myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider