Key result
Global work index (GWI) may serve as a potential prognostic determinant of outcomes in patients with heart failure with mildly reduced ejection fraction.
Why the study?
Does global work index (GWI) predict adverse outcomes in patients with heart failure with mildly reduced ejection fraction (HFmrEF)?
Does global work index (GWI) predict adverse outcomes in patients with heart failure with mildly reduced ejection fraction (HFmrEF)?
Answers are grounded in this paper and cite their sources.
Global work index (GWI) derived from non-invasive myocardial work analysis shows promise as a novel prognostic indicator for patients with heart failure with mildly reduced ejection fraction (HFmrEF).
ARNI), ischemic heart disease, conduction abnormalities such as bundle branch block, and the presence of implantable devices, as well as biochemical markers such as total bilirubin, serum sodium, and cholesterol levels. 3,4For heart failure with preserved ejection fraction H eart failure with mildly reduced ejection fraction (HFmrEF) has been defined in recent guidelines, 1,2 but the risk factors and prognostic predictors remain insufficiently established.In contrast, heart failure with reduced ejection fraction (HFrEF) has been extensively studied, with identified prognostic determinants including left ventricular ejection fraction (LVEF), sex, treatment with β-blockers or angiotensin receptor-neprilysin inhibitors Article p ????
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Jiro Sakamoto (2025) conducted an editorial in Heart failure with mildly reduced ejection fraction (HFmrEF). Global work index (GWI) was evaluated. Global work index (GWI) may serve as a potential prognostic determinant of outcomes in patients with heart failure with mildly reduced ejection fraction.
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