Key result
NADPH oxidase–derived reactive oxygen species drive cerebrovascular dysregulation and cognitive impairment in aging and hypertension.
Cerebrovascular oxidative stress mediated by NADPH oxidase is a shared pathogenic mechanism linking aging, hypertension, and Alzheimer disease to cognitive impairment, highlighting vascular NADPH oxidase inhibition as a potential therapeutic target.
Answers are grounded in this paper and cite their sources.
Positions NADPH oxidase inhibition as a candidate therapy for cognitive impairment; leaves open confirmation in randomized trials.
Aging, Alzheimer disease, and hypertension, major determinants of cognitive dysfunction, are associated with profound alterations in the structure and function of cerebral blood vessels. These vascular alterations may impair the delivery of energy substrates and nutrients to the active brain, and impede the clearance of potentially toxic metabolic byproducts. Reactive oxygen species derived form the enzyme NADPH oxidase are key pathogenic effectors of the cerebrovascular dysregulation. The resulting alterations in the homeostasis of the cerebral microenvironment may lead to cellular dysfunction and death and to cognitive impairment. The prominent role that cerebrovascular oxidative stress plays in conditions associated with cognitive impairment suggests new therapeutic opportunities to counteract and, possibly, reverse the devastating effects of cerebrovascular dysfunction on the brain.
No takes yet. Share an insight, caveat, or question.
Iadecola et al. (2008) conducted a review in Cognitive dysfunction associated with aging, hypertension, and Alzheimer disease. Aging, hypertension, and Alzheimer disease (mediated by NADPH oxidase-derived reactive oxygen species) was evaluated on Cerebrovascular dysfunction and cognitive impairment. Reactive oxygen species derived from NADPH oxidase are key pathogenic effectors of the cerebrovascular dysregulation and cognitive impairment associated with aging, hypertension, and Alzheimer disease.
Synapse has enriched 10 related papers. Consider them for comparative context: