Key result
Beta-blocker dispensing within 30 days post-AMI increased from 38.1% in 1995 to 67.9% in 2002 (OR 3.85; 95% CI 3.58-4.13), while ACE inhibitor use increased from 24.5% to 35.5%.
Observational
Yes
Prescription rates of beta-blockers and ACE inhibitors post-AMI increased significantly in Denmark between 1995 and 2002, though women, elderly, and diabetic patients remained undertreated.
Answers are grounded in this paper and cite their sources.
Increases in post-AMI beta-blocker and ACE inhibitor dispensing were associated with time; extends secular trend data but leaves open whether disparities in women, elderly, and diabetics persist.
OBJECTIVES: To study the use of beta-blockers and angiotensin-converting enzyme (ACE) inhibitors after acute myocardial infarction (AMI) in Denmark from 1995 to 2002. DESIGN: Information about patients with first AMI aged > or = 30 years and the dispensing of beta-blockers and ACE inhibitors from pharmacies within 30 d from discharge was obtained from the National Patient Registry and the Danish Registry of Medicinal Product Statistics. RESULTS: Beta-blocker use increased from 38.1% of patients in 1995 to 67.9% in 2002 (OR = 3.85, CI: 3.58-4.13). Women, elderly patients and patients taking loop-diuretics and antidiabetic drugs received beta-blockers less frequently, but patients taking loop-diuretics or antidiabetic drugs had the greatest increase. ACE inhibitor use increased from 24.5 to 35.5% (OR = 1.86, CI: 1.72-2.01). Women, patients aged < 60 years or > or = 80 years and patients not taking loop-diuretics received ACE inhibitors less frequently, but patients not taking loop-diuretics had the greatest increase. CONCLUSIONS: Beta-blocker use increased markedly post-AMI from 1995 to 2002, whereas ACE inhibitor use increased modestly. The results suggested undertreatment of women, elderly patients and people with diabetes.
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Gislason et al. (2005) conducted an observational in acute myocardial infarction. Beta-blocker prescription in 2002 vs. Beta-blocker prescription in 1995 was evaluated on Dispensing of beta-blockers within 30 days from discharge (OR 3.85, 95% CI 3.58-4.13). Beta-blocker dispensing within 30 days post-AMI increased from 38.1% in 1995 to 67.9% in 2002 (OR 3.85; 95% CI 3.58-4.13), while ACE inhibitor use increased from 24.5% to 35.5%.
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