Population
Guinea-pig right atria labelled with [3H]-noradrenaline or [3H]-dopamine
Comparison
Electrical field pulses with or without… vs Control conditions
Design
Preclinical
Authors
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Cautions against assuming alpha-2 feedback at moderate sympathetic drive in patients; leaves open its role during intense activation or uptake blockade.
In guinea-pig atria, auto-inhibitory feedback via alpha-2 adrenoceptors only modulates sympathetic transmitter release during near-maximal stimulation or when neuronal uptake is inhibited.
Angus et al. (1984) studied this question.
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