August 1, 1974Clinical and Experimental Pharmacology and Physiology

Resting and Stimulation-Induced Efflux of Tritium From Guinea-Pig Atria Incubated With 3h-Noradrenaline

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Population

Guinea-pig atria incubated with 3H-(-)-noradrenaline

Comparison

Field stimulation and pharmacological agents vs Resting state or absence of specific…

Design

Preclinical

Authors

MMM.W. McCullochUCLA Health MRM. J. RandUniversity of Sarajevo DSDavid StoryUnifor

Discussion

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Implication

Hypothesis-generating in guinea-pig atria; leaves open translation to human sympathetic control and clinical relevance.

Structured PICO

Population

Guinea-pig atria incubated with 3H-(-)-noradrenaline

Intervention

Field stimulation and pharmacological agents (tetrodotoxin, cocaine, guanethidine, tyramine, normetanephrine)

Comparator

Resting state or absence of specific pharmacological agents

Outcome

Efflux of radioactivity (resting and stimulation-induced) and force of atrial contractionssurrogate

This preclinical study demonstrates the mechanisms of noradrenaline efflux and contractile force modulation in guinea-pig atria by various pharmacological agents.

Cite This Study

McCulloch et al. (1974) studied this question.

synapsesocial.com/papers/6a89c865af65c378f7fd4977 https://doi.org/10.1111/j.1440-1681.1974.tb00550.x

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Resting and Stimulation-Induced Efflux of Tritium From Guinea-Pig Atria Incubated With 3h-Noradrenaline

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Resting and Stimulation-Induced Efflux of Tritium From Guinea-Pig Atria Incubated With 3h-Noradrenaline

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider