Key result
Nebivolol increased exercise tolerance and improved quality of life to a greater extent than bisoprolol and sotalol in 120 patients with ventricular arrhythmias and hypertension over 24 weeks.
Why the study?
The study was designed to compare the effects of bisoprolol, nebivolol, and sotalol on the functional state of patients with ventricular arrhythmias.
Does nebivolol or sotalol improve functional state compared to bisoprolol in patients with ventricular arrhythmias and hypertension or coronary heart disease?
RCT (n=120)
randomized
Does nebivolol or sotalol improve functional state compared to bisoprolol in patients with ventricular arrhythmias and hypertension or coronary heart disease?
In patients with ventricular arrhythmias and hypertension or coronary heart disease, nebivolol may be preferable to bisoprolol or sotalol due to a more pronounced positive effect on exercise tolerance and quality of life.
Aim.Compare the effects of bisoprolol, nebivolol and sotalol on the functional state of patients with ventricular arrhythmias (VA). Material and methods.120 patients with VA against the background of essential hypertension or its combination with coronary heart disease took part in the research, they were randomized into three groups for treatment with bisoprolol, nebivolol and sotalol. As part of combination therapy, patients were administered lisinopril, and if indicated, acetylsalicylic acid, atorvastatin. Initially and after 24 weeks of therapy the following was done: echocardiography, treadmill test, six-minute walk test, subjective assessment of quality of life, all-day monitoring of blood pressure and electrocardiogram. Results.With comparable hypotensive and antiarrhythmic effects, therapy with nebivolol increased exercise tolerance to a greater extent, in comparison with bisoprolol and sotalol. Nebivolol and sotalol improved the quality of life, in comparison with bisoprolol. Conclusion.In patients with VA against the background of essential hypertension or its combination with coronary heart disease as part of combination therapy the use of nebivolol may be preferable to bisoprolol or sotalol due to a more pronounced positive effect on the functional state.
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Shubitidze et al. (2020) conducted an RCT in Ventricular arrhythmias with essential hypertension or coronary heart disease (n=120). Nebivolol vs. Bisoprolol and sotalol was evaluated on Functional state (exercise tolerance and quality of life). Nebivolol increased exercise tolerance and improved quality of life to a greater extent than bisoprolol and sotalol in 120 patients with ventricular arrhythmias and hypertension over 24 weeks.
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