The study demonstrates that sympathomimetic antagonists and cocaine modulate autonomic responses in the isolated guinea-pig atrium by inhibiting parasympathetic and potentiating sympathetic effects.
These guinea-pig atrial findings should not alter clinical autonomic management; leaves open translation to intact mammalian or human physiology.
In the isolated guinea-pig atrium, phenoxybenzamine and other antagonists of sympathomimetic drugs and the adrenergic nerve blocking agent guanethidine inhibited the action of butyrylcholine and tyramine and potentiated the action of noradrenaline. Also in the isolated guinea-pig atrium, phenoxybenzamine and cocaine abolished the parasympathetic, and potentiated the sympathetic, effects of vagus stimulation.
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Benfey et al. (1961) studied this question.
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